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M94A0273.TXT
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1994-10-08
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Document 0273
DOCN M94A0273
TI Antifungal therapy of yeast infections.
DT 9412
AU Hay RJ; Department of Dermatology, United Medical Schools, Guy's;
Hospital, London, United Kingdom.
SO J Am Acad Dermatol. 1994 Sep;31(3 Pt 2):S6-9. Unique Identifier :
AIDSLINE MED/94358251
AB Candida infections of the skin and mucous membranes are common in both
healthy and immunocompromised patients. Management with topical azole or
polyene therapy is generally straightforward except in immunocompromised
patients with oropharyngeal infections and in Candida onychomycosis.
Oral candidosis in patients with AIDS generally requires oral therapy
with fluconazole, itraconazole, or ketoconazole. Continuous suppressive
therapy carries the risk of the development of clinical tolerance or
secondary drug resistance. In nail disease, oral antifungal therapy is
appropriate except in paronychia, for which topical azole antifungals
appear to be equally effective. In any case it is important to determine
whether Candida isolated from nail material is a true nail pathogen or
merely colonizing the nail plate. Distal erosion of the nail plate, the
presence of underlying host abnormalities such as Raynaud's disease, and
hyphae in the nail plate are clues that organism is invading the nail
plate.
DE Acquired Immunodeficiency Syndrome/COMPLICATIONS Administration,
Topical Antifungal Agents/*THERAPEUTIC USE Candidiasis,
Cutaneous/*DRUG THERAPY/IMMUNOLOGY/MICROBIOLOGY Candidiasis,
Oral/COMPLICATIONS/*DRUG THERAPY/IMMUNOLOGY/ MICROBIOLOGY Human
Immunocompromised Host Onychomycosis/*DRUG
THERAPY/IMMUNOLOGY/MICROBIOLOGY Paronychia/*DRUG
THERAPY/IMMUNOLOGY/MICROBIOLOGY JOURNAL ARTICLE REVIEW REVIEW,
TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).